Research

Our laboratory focuses on the complex roles of epicardial adipose tissue (EAT) and perivascular adipose tissue (PVAT) in cardiovascular health and disease. We investigate how these specialized adipose depots contribute to key conditions such as atherosclerosis, atrial fibrillation, and adverse myocardial remodeling. Utilizing advanced technologies like single-nucleus RNA sequencing, cutting-edge bioinformatics, histological and biochemical techniques, we strive to uncover novel therapeutic targets to improve cardiovascular outcomes.

A major focus is the role of PVAT in vascular homeostasis and atherosclerosis resistance, particularly differences between the left internal mammary artery and the right coronary artery. We aim to understand the mechanisms driving regional differences in atherosclerosis risk. Concurrently, we explore how EAT-derived chemokines recruit immune cells and contribute to inflammation in post-operative atrial fibrillation. By analyzing adipocyte heterogeneity and metabolic adaptations, we seek to identify therapeutic strategies to prevent atherosclerosis, arrhythmias, and heart failure.