Welcome to the Tran Lab in the Division of Cardiovascular Medicine

Research focus: 

• Understanding the molecular mechanisms by which epicardial adipose tissue contributes to adverse cardiac remodeling
• Exploring the role of epicardial adipocytes in immune-mediated electroanatomic remodeling to increase vulnerability to post-operative atrial fibrillation
• Investigating aberrant adipogenesis that leads to adverse structural remodeling 

Representative publications

• Tran KV, Brown EL, DeSouza T, Jespersen NZ, Nandrup-Bus C, Yang Q, Yang Z, Desai A, Min SY, Rojas-Rodriguez R, Lundh M, Feizi A, Willenbrock H, Larsen TJ, Severinsen MCK, Malka K, Mozzicato AM, Deshmukh AS, Emanuelli B, Pedersen BK, Fitzgibbons T, Scheele C, Corvera S, Nielsen S. Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473. Nat Metab. 2020 May;2(5):397-412. 
• Tran KV, Majka J, Sanghai S, Sardana M, Lessard D, Milstone Z, Tanriverdi K, Freedman JE, Fitzgibbons TP, McManus D. Micro-RNAs Are Related to Epicardial Adipose Tissue in Participants With Atrial Fibrillation: Data From the MiRhythm Study. Front Cardiovasc Med. 2019 Aug 14;6:115. 
• Tran KV, Fitzgibbons T, Min SY, DeSouza T, Corvera S. Distinct adipocyte progenitor cells are associated with regional phenotypes of perivascular aortic fat in mice. Mol Metab. 2018 Mar;9:199-206.
  
  

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