Feb 14, 2023
Coming up with new ways to treat COVID-19 is at the *heart* of BMB.
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We study biological and ultrastructural delineation of the interactions (binding, entry, replication) of human pathogenic viruses and their host cells.
We work to identify potential steps or targets worthy of therapeutic intervention to treat virus-driven diseases in humans.
We utilize in vitro cell culture model systems, virological assays, molecular biology tools, imaging, and Cryo-EM techniques.
As part of the Schiffer Lab, we cultivate a vibrant culture that supports academic research.
Anti-SARS-CoV-2 Activity of Adamantanes In Vitro and in Animal Models of Infection.
Lim SY, Guo Z, Liu P, McKay LGA, Storm N, Griffiths A, Qu MD, Finberg RW, Somasundaran M, Wang JP.
COVID. 2022 Nov;2(11):1551-1563. doi: 10.3390/covid2110111. Epub 2022 Oct 28. PMID: 37274537; PMCID: PMC10238102.
The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization.
Bohn MF, Shandilya SMD, Silvas TV, Nalivaika EA, Kouno T, Kelch BA, Ryder SP, Kurt-Yilmaz N, Somasundaran M, Schiffer CA.
Structure. 2015 May 5;23(5):903-911. doi: 10.1016/j.str.2015.03.016. Epub 2015 Apr 23. PMID: 25914058; PMCID: PMC4874493.
Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks.
Huang QJ, Song K, Xu C, Bolon DNA, Wang JP, Finberg RW, Schiffer CA, Somasundaran M.
Structure. 2022 May 5;30(5):777-786.e3. doi: 10.1016/j.str.2022.02.014. Epub 2022 Mar 14. PMID: 35290796; PMCID: PMC9610019.
