Site Menu
Buscar Close Search
Buscar Close Search
Page Menu

Publication Spotlights

 

Congratulations on our team's most recent publication achievements!


SIMS training A recent publication on teaching palliative care to neurology residents at UMass in a simulated setting showcases the collaboration between palliative care and neurology in a recent article published in Neurology Journal titled Curriculum Innovations: Enhancing skills in serious illness communication in Neurology Residents Using Simulation: 

Read the article published by UMass Chan News, https://www.umassmed.edu/medicine/research/researchers-in-the-news/palliative-care-and-neurology-collaborate-to-develop-curriculum-that-aims-to-improve-serious-illness-communication-skills-for-neurology-residents/ 

January 2025 

Author, Bridgette Van Zundert, first author, of the January 2025 publication in SpencerNature journal of the Subcellular Biochemistry book series titled, Epigenetics in Neurodegenerative Diseases. 

Author(s), Mustafa Al Gburi, Maria Mazzola, Martina Absinta, Maria I Gaitan, Daniel S Reich, Sathish K Dundamadappa, Christopher C Hemond, of the January 2025 publication in Sage Journals titled, Paramagnetic rim lesion formation is predicted by the initial gadlinium-enhancing lesion diameter.  

Author(s), Elif O Dogan, Sean R Simonini, James Bouley, Alexandra Weiss, Robert H Brown Jr, Nils Henninger, of the January 2025 publication in Annals of Neurology journal titled, Genetic Ablationof Sarm1 Mitigates Disease Acceleration after Traumatic Brain Injury in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis  

December 2024 

Author(s) Jonathan Sundstrom, Nathaniel J Barton, Pepper Dawes, Liam F Murray, Meagan N Olson, Khanh Tran, Samantha M Chigas, Adrian R Orszulak, Yingleong Chan, Elaine T Lim, of the December 2024 publication in Cells Journal titled, Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer’s Disease and Autoimmune Diseases 

Access to the PubMed list of publications

Total: displaying 15 out of 50 results

  • A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

    viernes, febrero 07, 2025
    Author(s): Xihao Li,Han Chen,Margaret Sunitha Selvaraj,Eric Van Buren,Hufeng Zhou,Yuxuan Wang,Ryan Sun,Zachary R McCaw,Zhi Yu,Min-Zhi Jiang,Daniel DiCorpo,Sheila M Gaynor,Rounak Dey,Donna K Arnett,Emelia J Benjamin,Joshua C Bis,John Blangero,Eric Boerwinkle,Donald W Bowden,Jennifer A Brody,Brian E Cade,April P Carson,Jenna C Carlson,Nathalie Chami,Yii-Der Ida Chen,Joanne E Curran,Paul S de Vries,Myriam Fornage,Nora Franceschini,Barry I Freedman,Charles Gu,Nancy L Heard-Costa,Jiang He,Lifang Hou,Yi-Jen Hung,Marguerite R Irvin,Robert C Kaplan,Sharon L R Kardia,Tanika N Kelly,Iain Konigsberg,Charles Kooperberg,Brian G Kral,Changwei Li,Yun Li,Honghuang Lin,Ching-Ti Liu,Ruth J F Loos,Michael C Mahaney,Lisa W Martin,Rasika A Mathias,Braxton D Mitchell,May E Montasser,Alanna C Morrison,Take Naseri,Kari E North,Nicholette D Palmer,Patricia A Peyser,Bruce M Psaty,Susan Redline,Alexander P Reiner,Stephen S Rich,Colleen M Sitlani,Jennifer A Smith,Kent D Taylor,Hemant K Tiwari,Ramachandran S Vasan,Satupa'itea Viali,Zhe Wang,Jennifer Wessel,Lisa R Yanek,Bing Yu,NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium,Josée Dupuis,James B Meigs,Paul L Auer,Laura M Raffield,Alisa K Manning,Kenneth M Rice,Jerome I Rotter,Gina M Peloso,Pradeep Natarajan,Zilin Li,Zhonghua Liu,Xihong Lin
    Source: Nature computational science
    Large-scale whole-genome sequencing (WGS) studies have improved our understanding of the contributions of coding and noncoding rare variants to complex human traits. Leveraging association effect sizes across multiple traits in WGS rare variant association analysis can improve statistical power over single-trait analysis, and also detect pleiotropic genes and regions. Existing multi-trait methods have limited ability to perform rare variant analysis of large-scale WGS data. We propose...

  • Reporting standards in randomized controlled trials involving neuro-oncology caregivers: A systematic review report from the RANO-Cares working group

    viernes, febrero 07, 2025
    Author(s): Florien W Boele,Caroline Hertler,Paula Sherwood,David Cachia,Linda Dirven,Jacob S Young,Tobias Walbert,Macy Stockdill,Eduardo Rodriguez Almaraz,Karin Piil
    Source: Neuro-oncology practice
    CONCLUSIONS: Whilst there are opportunities to enhance reporting standards, RCTs that include neuro-oncology caregiver outcomes generally adhere to high-quality reporting standards and have low risk of bias, indicating good potential to impact clinical practice.

  • Research Priorities in Neuropalliative Care: A Consensus Statement From the International Neuropalliative Care Society

    lunes, febrero 03, 2025
    Author(s): Winnie K Lau,Corey R Fehnel,Zachary A Macchi,Ambereen K Mehta,Manon Auffret,Jori F Bogetz,Jori E Fleisher,Jerome J Graber,Heather E Leeper,Heena R Manglani-Terranova,Susanne Muehlschlegel,Emily L Mroz,Elizabeth J Pedowitz,Usha Ramanathan,Max Sarmet,Nathan A Shlobin,Leonard Sokol,Susan Allyson Weeks,Jiayun Xu,Helen Bundy Medsger,Claire J Creutzfeldt,Ana-Maria Vranceanu,Darin B Zahuranec,David Y Hwang
    Source: JAMA neurology
    CONCLUSIONS AND RELEVANCE: This Special Communication outlines some of the most pressing neuropalliative care research needs, the advancement of which will best serve patients of all ages living with serious neurologic diseases and their care partners. Research funding mechanisms are needed to support and sustain impactful work in this field.

  • Emergent Carotid Stenting During Thrombectomy in Tandem Occlusions Secondary to Dissection: A STOP-CAD Secondary Study

    jueves, enero 30, 2025
    Author(s): João André Sousa,Marc Rodrigo-Gisbert,Liqi Shu,Anqi Luo,Han Xiao,Noor A Mahmoud,Asghar Shah,Ana Luyza Oliveira Santos,Marina Moore,Daniel M Mandel,Mirjam R Heldner,Vasco Barata,Sara Bernardo-Castro,Nils Henninger,Jayachandra Muppa,Marcel Arnold,Ahmad Nehme,Aaron Rothstein,Ossama Khazaal,Josefin E Kaufmann,Stefan T Engelter,Christopher Traenka,Issa Metanis,Ronen R Leker,Christian H Nolte,Malik Ghannam,Edgar A Samaniego,Mohammad AlMajali,Alexandre Y Poppe,Michele Romoli,Jennifer A Frontera,Marialuisa Zedde,Wayneho Kam,Brian Mac Grory,Faddi Ghassan Saleh Velez,Tamra Ranasinghe,James E Siegler,Adeel S Zubair,João Pedro Marto,Piers Klein,Thanh N Nguyen,Mohamad Abdalkader,Gabriel Paulo Mantovani,Alexis N Simpkins,Shayak Sen,Marwa Elnazeir,Shadi Yaghi,Joao Sargento-Freitas,Manuel Requena
    Source: Stroke
    Background: The optimal endovascular management of cervical carotid dissection causing tandem occlusion remains uncertain. We investigated the impact of emergent carotid stenting during endovascular treatment (EVT) for acute ischemic stroke (AIS) in patients with tandem occlusion secondary to cervical carotid artery dissection. Methods: This was a secondary analysis of patients treated with EVT for AIS due to occlusive carotid artery dissection and tandem occlusion included in the retrospective...

  • Efficacy and Safety of Mechanical Thrombectomy in Distal Medium Middle Cerebral Artery Occlusion Ischemic Stroke Patients on Low-Dose Aspirin

    martes, enero 28, 2025
    Author(s): Hamza A Salim,Vivek Yedavalli,Fathi Milhem,Basel Musmar,Nimer Adeeb,Motaz Daraghma,Kareem El Naamani,Nils Henninger,Sri Hari Sundararajan,Anna Kuhn,Jane Khalife,Sherief Ghozy,Luca Scarcia,Benjamin Yq Tan,Robert Regenhardt,Jeremy Heit,Nicole Mariantonia Cancelliere,Joshua Bernstock,Aymeric Rouchaud,Jens Fiehler,Sunil A Sheth,Ajit S Puri,Christian Dyzmann,Marco Colasurdo,Leonardo Renieri,João Pedro Filipe,Pablo Harker,Răzvan Alexandru Radu,Mohamad Abdalkader,Piers Klein,Thomas Marrota,Julian Spears,Takahiro Ota,Ashkan Mowla,Pascal Jabbour,Arundhati Biswas,Frederic Clarencon,James E Siegler,Thanh N Nguyen,Ricardo Varela,Amanda Baker,Muhammed Amir Essibayi,David Altschul,Nestor Gonzalez,Markus Möhlenbruch,Vincent Costalat,Benjamin Gory,Christian Stracke,Constantin Hecker,Hamza Shaikh,Christoph Griessenaur,David S Liebeskind,Alessandro Pedicelli,Andrea Alexandre,Illario Tancredi,Tobias Djamsched Faizy,Erwah Kalsoum,Max Wintermark,Boris Lubicz,Aman B Patel,Vitor Mendes Pereira,Adrien Guenego,Adam Dmytriw
    Source: International journal of stroke : official journal of the International Stroke Society
    CONCLUSIONS: Pre-stroke low-dose aspirin was associated with improved functional outcomes and reduced mortality in patients with DMVO undergoing MT, without a significant increase in sICH. These findings suggest that low-dose aspirin may be safe and associated with more frequent excellent outcomes for this patient population. Further prospective studies are needed to validate these results and assess long-term outcomes.

  • Clinical outcomes of patients with unsuccessful mechanical thrombectomy versus best medical management of medium vessel occlusion stroke in the middle cerebral artery territory

    viernes, enero 24, 2025
    Author(s): Tobias D Faizy,Vivek Yedavalli,Hamza Adel Salim,Dhairya A Lakhani,Basel Musmar,Nimer Adeeb,Muhammed Amir Essibayi,Motaz Daraghma,Kareem El Naamani,Nils Henninger,Sri Hari Sundararajan,Anna Luisa Kuhn,Jane Khalife,Sherief Ghozy,Luca Scarcia,Leonard Ll Yeo,Benjamin Yq Tan,Robert W Regenhardt,Jeremy Josef Heit,Nicole M Cancelliere,Aymeric Rouchaud,Jens Fiehler,Sunil A Sheth,Ajit S Puri,Christian Dyzmann,Marco Colasurdo,Leonardo Renieri,João Pedro Filipe,Pablo Harker,Răzvan Alexandru Radu,Mohamad Abdalkader,Piers Klein,Thomas R Marotta,Julian Spears,Takahiro Ota,Ashkan Mowla,Pascal Jabbour,Arundhati Biswas,Frédéric Clarençon,James E Siegler,Thanh N Nguyen,Ricardo Varela,Amanda Baker,David Altschul,Nestor Gonzalez,Markus A Möhlenbruch,Vincent Costalat,Benjamin Gory,Christian Paul Stracke,Constantin Hecker,Gaultier Marnat,Hamza Shaikh,Christoph J Griessenauer,David S Liebeskind,Alessandro Pedicelli,Andrea Maria Alexandre,Illario Tancredi,Erwah Kalsoum,Max Wintermark,Boris Lubicz,Aman B Patel,Vitor Mendes Pereira,Adam A Dmytriw,Adrien Guenego,MAD-MT Investigators
    Source: Journal of neurointerventional surgery
    CONCLUSION: Unsuccessful MT for MeVO was linked to worse outcomes than best MM. These findings highlight the risks of prolonged attempts and emphasize the importance of efficient procedural decision-making to reduce complications and improve patient outcomes.

  • Psychosocial Support Needs and Preferences Among Family Caregivers of ICU Patients with Severe Acute Brain Injury: A Qualitative Thematic Analysis

    viernes, enero 17, 2025
    Author(s): David Y Hwang,Mira Reichman,Sarah M Bannon,Kate Meurer,Rina Kubota,Jisoo Kim,Nithyashri Baskaran,Qiang Zhang,Nathan S Fishbein,Kaitlyn Lichstein,Alexander M Presciutti,Emily C Woodworth,Melissa Motta,Susanne Muehlschlegel,Michael E Reznik,Matthew N Jaffa,Claire J Creutzfeldt,Corey R Fehnel,Amanda D Tomlinson,Craig A Williamson,Ana-Maria Vranceanu,Coma Family Investigators
    Source: Neurocritical care
    CONCLUSIONS: Our findings provide specific recommendations to justify and inform the development and adaptation of psychosocial support services for SABI caregivers for delivery in the ICU and after discharge.

  • Epigenetics in Neurodegenerative Diseases

    viernes, enero 17, 2025
    Author(s): Brigitte van Zundert,Martin Montecino
    Source: Sub-cellular biochemistry
    Healthy brain functioning requires a continuous fine-tuning of gene expression, involving changes in the epigenetic landscape and 3D chromatin organization. Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD) are three multifactorial neurodegenerative diseases (NDDs) that are partially explained by genetics (gene mutations and genetic risk factors) and influenced by non-genetic factors (i.e., aging, lifestyle, and environmental conditions). Examining...

  • Epigenetics in Learning and Memory

    viernes, enero 17, 2025
    Author(s): Brigitte van Zundert,Martin Montecino
    Source: Sub-cellular biochemistry
    In animals, memory formation and recall are essential for their survival and for adaptations to a complex and often dynamically changing environment. During memory formation, experiences prompt the activation of a selected and sparse population of cells (engram cells) that undergo persistent physical and/or chemical changes allowing long-term memory formation, which can last for decades. Over the past few decades, important progress has been made on elucidating signaling mechanisms by which...

  • Paramagnetic rim lesion formation is predicted by the initial gadolinium-enhancing lesion diameter

    viernes, enero 17, 2025
    Author(s): Mustafa Al Gburi,Maria Mazzola,Martina Absinta,María I Gaitán,Daniel S Reich,Sathish K Dundamadappa,Christopher C Hemond
    Source: Multiple sclerosis (Houndmills, Basingstoke, England)
    CONCLUSIONS: The long-axis diameter of a CEL is the best translational predictor of subsequent PRL formation at follow-up. This measure holds promise as a method to identify patients at high risk of chronic active lesion formation during the acute inflammatory window.

  • Outcomes of mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke patients with ASPECTS 4-5 vs. 6-7: a retrospective, multicenter, and multinational study

    miércoles, enero 15, 2025
    Author(s): Basel Musmar,Hamza Adel Salim,Nimer Adeeb,Vivek Yedavalli,Dhairya Lakhani,Kareem El Naamani,Nils Henninger,Sri Hari Sundararajan,Anna Luisa Kühn,Jane Khalife,Sherief Ghozy,Luca Scarcia,Benjamin Y Q Tan,Robert W Regenhardt,Jeremy J Heit,Nicole M Cancelliere,Joshua D Bernstock,Aymeric Rouchaud,Jens Fiehler,Sunil Sheth,Ajit S Puri,Christian Dyzmann,Marco Colasurdo,Xavier Barreau,Leonardo Renieri,João Pedro Filipe,Pablo Harker,Răzvan Alexandru Radu,Mohamad Abdalkader,Piers Klein,Thomas R Marotta,Julian Spears,Takahiro Ota,Ashkan Mowla,Pascal Jabbour,Arundhati Biswas,Frédéric Clarençon,James E Siegler,Thanh N Nguyen,Ricardo Varela,Amanda Baker,Muhammed Amir Essibayi,David Altschul,Nestor R Gonzalez,Markus A Möhlenbruch,Vincent Costalat,Benjamin Gory,Christian Paul Stracke,Mohammad Ali Aziz-Sultan,Constantin Hecker,Hamza Shaikh,David S Liebeskind,Alessandro Pedicelli,Andrea M Alexandre,Illario Tancredi,Tobias D Faizy,Erwah Kalsoum,Boris Lubicz,Aman B Patel,Vitor Mendes Pereira,Adrien Guenego,Adam A Dmytriw,MAD MT Investigators
    Source: Neuroradiology
    CONCLUSION: MT may be associated with improved outcomes in patients with moderate-to-low ASPECTS (6-7), though the lack of a control group limits definitive conclusions about its effectiveness. In patients with very low ASPECTS (4-5), higher rates of hemorrhagic complications and poorer outcomes were observed, but this does not necessarily preclude the use of MT. These findings highlight the need for further research and careful patient selection.

  • A Real-World Prospective Multiple Sclerosis Pregnancy Registry in the United States: PREG-MS

    miércoles, enero 15, 2025
    Author(s): Maria K Houtchens,Maria Claudia Manieri,Tatenda Dawn Mahlanza,Jeta Pol-Patil,Eric C Klawiter,Andrew J Solomon,Ellen Lathi,Joshua Katz,Carolina Ionete,Idanis Berrios Morales,Christopher Severson,Jonathan Zurawski,James M Stankiewicz,Ann Cabot,Adele Dessa Sadovnick
    Source: Neurology. Clinical practice
    BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) affects more than 1 million people in the United States, including reproductive-age women. There has been a paucity of prospective, pregnancy registries based on MS disease rather than medication exposures. A prospective MS pregnancy registry (PREG-MS) was established in 2017 as a prospective, single-cohort, real-world MS pregnancy registry in New England States of the United States, with goals to evaluate (1) course of MS and disease-modifying...

  • Genetic Ablation of Sarm1 Mitigates Disease Acceleration after Traumatic Brain Injury in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

    viernes, enero 10, 2025
    Author(s): Elif O Dogan,Sean R Simonini,James Bouley,Alexandra Weiss,Robert H Brown,Nils Henninger
    Source: Annals of neurology
    OBJECTIVE: Approximately 20% of familial cases of amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene encoding superoxide dismutase 1 (SOD1). Epidemiological data have identified traumatic brain injury (TBI) as an exogenous risk factor for ALS; however, the mechanisms by which TBI may worsen SOD1 ALS remain largely undefined.

  • Education Research: The Neurohumanities in Training: Integrating a Humanities Curriculum Within Neurology Residency Programs

    viernes, enero 03, 2025
    Author(s): Mattia Rosso,Tatiana Greige,Charles Palmer,Greta Solinap Peng,Rumyar V Ardakani,Alexander Frolov,Manju George,Raphael Arellano Carandang,Galina Gheihman,Michael P H Stanley
    Source: Neurology. Education
    BACKGROUND AND OBJECTIVES: Perhaps stemming from the central role of detailed examinations and a focus on the subjective sphere that grounds their clinical practice, neurologists have frequently opined on experiences traditionally a province of humanities. The increasingly technological focus on medical education and care can be seen to devalue the subjective aspects of medicine. As a counter to this, we report on the existence of neurohumanities curricula within neurology residency training.

  • Author Correction: Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

    viernes, diciembre 20, 2024
    Author(s): Naziia Kurmasheva,Aida Said,Boaz Wong,Priscilla Kinderman,Xiaoying Han,Anna H F Rahimic,Alena Kress,Madalina E Carter-Timofte,Emilia Holm,Demi van der Horst,Christoph F Kollmann,Zhenlong Liu,Chen Wang,Huy-Dung Hoang,Elina Kovalenko,Maria Chrysopoulou,Krishna Sundar Twayana,Rasmus N Ottosen,Esben B Svenningsen,Fabio Begnini,Anders E Kiib,Florian E H Kromm,Hauke J Weiss,Daniele Di Carlo,Michela Muscolini,Maureen Higgins,Mirte van der Heijden,Rozanne Arulanandam,Angelina Bardoul,Tong Tong,Attila Ozsvar,Wen-Hsien Hou,Vivien R Schack,Christian K Holm,Yunan Zheng,Melanie Ruzek,Joanna Kalucka,Laureano de la Vega,Walid A M Elgaher,Anders R Korshoej,Rongtuan Lin,John Hiscott,Thomas B Poulsen,Luke A O'Neill,Dominic G Roy,Markus M Rinschen,Nadine van Montfoort,Jean-Simon Diallo,Henner F Farin,Tommy Alain,David Olagnier
    Source: Nature communications
    No abstract

  • Alzheimer's disease-associated CD83(+) microglia are linked with increased immunoglobulin G4 and human cytomegalovirus in the gut, vagal nerve, and brain

    jueves, diciembre 19, 2024
    Author(s): Benjamin P Readhead,Diego F Mastroeni,Qi Wang,Maria A Sierra,Camila de Ávila,Tajudeen O Jimoh,Jean-Vianney Haure-Mirande,Kristina E Atanasoff,Jennifer Nolz,Crystal Suazo,Nathaniel J Barton,Adrian R Orszulak,Samantha M Chigas,Khanh Tran,Anne Mirza,Krista Ryon,Jacqueline Proszynski,Deena Najjar,Joel T Dudley,Sean T H Liu,Sam Gandy,Michelle E Ehrlich,Eric Alsop,Jerry Antone,Rebecca Reiman,Cory Funk,Rebecca L Best,Michael Jhatro,Kathy Kamath,John Shon,Timothy F Kowalik,David A Bennett,Winnie S Liang,Geidy E Serrano,Thomas G Beach,Kendall Van Keuren-Jensen,Christopher E Mason,Yingleong Chan,Elaine T Lim,Domenico Tortorella,Eric M Reiman
    Source: Alzheimer's & dementia : the journal of the Alzheimer's Association
    INTRODUCTION: While there may be microbial contributions to Alzheimer's disease (AD), findings have been inconclusive. We recently reported an AD-associated CD83(+) microglia subtype associated with increased immunoglobulin G4 (IgG4) in the transverse colon (TC).

  • Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer's Disease and Autoimmune Diseases

    martes, diciembre 17, 2024
    Author(s): Jonathan Sundstrom,Emma Vanderleeden,Nathaniel J Barton,Sambra D Redick,Pepper Dawes,Liam F Murray,Meagan N Olson,Khanh Tran,Samantha M Chigas,Adrian R Orszulak,George M Church,Benjamin Readhead,Hyung Suk Oh,David M Harlan,David M Knipe,Jennifer P Wang,Yingleong Chan,Elaine T Lim
    Source: Cells
    Viral infections leading to inflammation have been implicated in several common diseases, such as Alzheimer's disease (AD) and type 1 diabetes (T1D). Of note, herpes simplex virus 1 (HSV-1) has been reported to be associated with AD. We sought to identify the transcriptomic changes due to HSV-1 infection and anti-viral drug (acyclovir, ACV) treatment of HSV-1 infection in dissociated cells from human cerebral organoids (dcOrgs) versus stem cell-derived pancreatic islets (sc-islets) to gain...

  • Advancing LGBTQI+ Equity in Neurology: An AAN Position Statement

    martes, diciembre 10, 2024
    Author(s): Nicole Rosendale,Z Paige L'Erario,Deanna Ekholm,Wissam Deeb,Gwen Zeigler,Cole A Harrington,Richard T Benson,Nimish A Mohile,Roy H Hamilton,H E Hinson,Diversity, Equity, and Inclusion Committee
    Source: Neurology
    No abstract

  • Differential outcomes and treatment in non-traumatic carotid versus vertebral cervical artery dissection: A national inpatient sample study

    domingo, diciembre 08, 2024
    Author(s): Elizabeth Lee,Liqi Shu,Setareh Salehi Omran,Eric D Goldstein,Nils Henninger,Thanh N Nguyen,James E Siegler,Lukas Strelecky,Farhan Khan,Christoph Stretz,Karen L Furie,Shadi Yaghi
    Source: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
    CONCLUSION: Our study underscores distinct comorbidity profiles and treatment patterns between non-traumatic carotid dissection and vertebral dissection groups. These findings advocate for tailored treatment strategies based on dissection type to optimize patient outcomes.

  • Development of web- and mobile-based shared decision-making tools in the neurological intensive care unit

    viernes, diciembre 06, 2024
    Author(s): Winnie L Liu,Lidan Zhang,Soussan Djamasbi,Bengisu Tulu,Susanne Muehlschlegel
    Source: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
    In the neurological intensive care unit (neuroICU), patients with severe acute brain injury (SABI) are rendered unable to make their own healthcare decisions. The responsibility of making life-or-death decisions, such as goals of care, is carried by surrogate decision-makers, usually families. In addition to the burden of decision-making, the emotional burden on families is further compounded by prognostication uncertainty, time-pressure for decision-making, and difficulties in understanding and...

  • Endovascular therapy versus medical management in isolated anterior cerebral artery acute ischemic stroke: a multinational multicenter propensity score-weighted study

    viernes, noviembre 29, 2024
    Author(s): Hamza Adel Salim,Benjamin Pulli,Vivek Yedavalli,Fathi Milhem,Basel Musmar,Nimer Adeeb,Dhairya A Lakhani,Muhammed Amir Essibayi,Jeremy Josef Heit,Tobias D Faizy,Kareem El Naamani,Nils Henninger,Sri Hari Sundararajan,Anna Luisa Kuhn,Jane Khalife,Sherief Ghozy,Luca Scarcia,Leonard Ll Yeo,Benjamin Yq Tan,Robert W Regenhardt,Nicole M Cancelliere,Aymeric Rouchaud,Jens Fiehler,Sunil A Sheth,Ajit S Puri,Christian Dyzmann,Marco Colasurdo,Leonardo Renieri,João Pedro Filipe,Pablo Harker,Răzvan Alexandru Radu,Mohamad Abdalkader,Piers Klein,Thomas R Marotta,Julian Spears,Takahiro Ota,Ashkan Mowla,Pascal Jabbour,Arundhati Biswas,Frédéric Clarençon,James E Siegler,Thanh N Nguyen,Ricardo Varela,Amanda Baker,David Altschul,Nestor Gonzalez,Markus A Möhlenbruch,Vincent Costalat,Benjamin Gory,Paul Stracke,Constantin Hecker,Gaultier Marnat,Hamza Shaikh,Christoph J Griessenauer,David S Liebeskind,Alessandro Pedicelli,Andrea Maria Alexandre,Illario Tancredi,Erwah Kalsoum,Boris Lubicz,Aman B Patel,Vitor Mendes Pereira,Max Wintermark,Adrien Guenego,Adam A Dmytriw,MAD-MT Investigators
    Source: Journal of neurointerventional surgery
    CONCLUSIONS: EVT showed high procedural success but did not significantly improve functional outcomes or mortality compared with BMT in patients with ACAo. Further randomized trials are needed to clarify EVT's role in ACAo.

  • Inflammatory cytokines disrupt astrocyte exosomal HepaCAM-mediated protection against neuronal excitotoxicity in the SOD1G93A ALS model

    miércoles, noviembre 27, 2024
    Author(s): Shijie Jin,Yang Tian,Jonathan Hacker,Xuan Chen,Marcela Bertolio,Caroline Reynolds,Rachel Jarvis,Jingwen Hu,Vanessa Promes,Dilara Halim,Fen-Biao Gao,Yongjie Yang
    Source: Science advances
    Astrocyte secreted signals substantially affect disease pathology in neurodegenerative diseases. It remains little understood about how proinflammatory cytokines, such as interleukin-1α/tumor necrosis factor-α/C1q (ITC), often elevated in neurodegenerative diseases, alter astrocyte-secreted signals and their effects in disease pathogenesis. By selectively isolating astrocyte exosomes (A-Exo.) and employing cell type-specific exosome reporter mice, our current study showed that ITC cytokines...

  • Quantifying and mitigating motor phenotypes induced by antisense oligonucleotides in the central nervous system

    sábado, octubre 26, 2024
    Author(s): Michael P Moazami,Julia M Rembetsy-Brown,Samantha L Sarli,Holly R McEachern,Feng Wang,Masahiro Ohara,Atish Wagh,Karen Kelly,Pranathi Meda Krishnamurthy,Alexandra Weiss,Miklos Marosfoi,Robert M King,Mona Motwani,Heather Gray-Edwards,Katherine A Fitzgerald,Robert H Brown,Jonathan K Watts
    Source: Molecular therapy : the journal of the American Society of Gene Therapy
    Antisense oligonucleotides (ASOs) are emerging as a promising class of therapeutics for neurological diseases. When injected directly into cerebrospinal fluid, ASOs distribute broadly across brain regions and exert long-lasting therapeutic effects. However, many phosphorothioate (PS)-modified gapmer ASOs show transient motor phenotypes when injected into the cerebrospinal fluid, ranging from reduced motor activity to ataxia or acute seizure-like phenotypes. Using a behavioral scoring assay...

  • Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death

    viernes, octubre 25, 2024
    Author(s): Pablo Martínez,Mónica Silva,Sebastián Abarzúa,María Florencia Tevy,Enrique Jaimovich,Martha Constantine-Paton,Fernando J Bustos,Brigitte van Zundert
    Source: Molecular medicine (Cambridge, Mass.)
    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of motoneurons (MNs), and despite progress, there is no effective treatment. A large body of evidence shows that astrocytes expressing ALS-linked mutant proteins cause non-cell autonomous toxicity of MNs. Although MNs innervate muscle fibers and ALS is characterized by the early disruption of the neuromuscular junction (NMJ) and axon degeneration, there are controversies about whether muscle...

  • Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data

    martes, octubre 22, 2024
    Author(s): Sara Saez-Atienzar,Cleide Dos Santos Souza,Ruth Chia,Selina N Beal,Ileana Lorenzini,Ruili Huang,Jennifer Levy,Camelia Burciu,Jinhui Ding,J Raphael Gibbs,Ashley Jones,Ramita Dewan,Viviana Pensato,Silvia Peverelli,Lucia Corrado,Joke J F A van Vugt,Wouter van Rheenen,Ceren Tunca,Elif Bayraktar,Menghang Xia,International ALS Genomics Consortium,ITALSGEN Consortium,SLAGEN Consortium,Project MinE ALS Sequencing Consortium,Alfredo Iacoangeli,Aleksey Shatunov,Cinzia Tiloca,Nicola Ticozzi,Federico Verde,Letizia Mazzini,Kevin Kenna,Ahmad Al Khleifat,Sarah Opie-Martin,Flavia Raggi,Massimiliano Filosto,Stefano Cotti Piccinelli,Alessandro Padovani,Stella Gagliardi,Maurizio Inghilleri,Alessandra Ferlini,Rosario Vasta,Andrea Calvo,Cristina Moglia,Antonio Canosa,Umberto Manera,Maurizio Grassano,Jessica Mandrioli,Gabriele Mora,Christian Lunetta,Raffaella Tanel,Francesca Trojsi,Patrizio Cardinali,Salvatore Gallone,Maura Brunetti,Daniela Galimberti,Maria Serpente,Chiara Fenoglio,Elio Scarpini,Giacomo P Comi,Stefania Corti,Roberto Del Bo,Mauro Ceroni,Giuseppe Lauria Pinter,Franco Taroni,Eleonora Dalla Bella,Enrica Bersano,Charles J Curtis,Sang Hyuck Lee,Raymond Chung,Hamel Patel,Karen E Morrison,Johnathan Cooper-Knock,Pamela J Shaw,Gerome Breen,Richard J B Dobson,Clifton L Dalgard,American Genome Center,Sonja W Scholz,Ammar Al-Chalabi,Leonard H van den Berg,Russell McLaughlin,Orla Hardiman,Cristina Cereda,Gianni Sorarù,Sandra D'Alfonso,Siddharthan Chandran,Suvankar Pal,Antonia Ratti,Cinzia Gellera,Kory Johnson,Tara Doucet-O'Hare,Nicholas Pasternack,Tongguang Wang,Avindra Nath,Gabriele Siciliano,Vincenzo Silani,Ayşe Nazlı Başak,Jan H Veldink,William Camu,Jonathan D Glass,John E Landers,Adriano Chiò,Rita Sattler,Christopher E Shaw,Laura Ferraiuolo,Isabella Fogh,Bryan J Traynor
    Source: Cell genomics
    Repeat expansions in the C9orf72 gene are the most common genetic cause of (ALS) and frontotemporal dementia (FTD). Like other genetic forms of neurodegeneration, pinpointing the precise mechanism(s) by which this mutation leads to neuronal death remains elusive, and this lack of knowledge hampers the development of therapy for C9orf72-related disease. We used an agnostic approach based on genomic data (n = 41,273 ALS and healthy samples, and n = 1,516 C9orf72 carriers) to overcome these...

  • Phenotyping in vivo chronic inflammation in multiple sclerosis by combined 11C-PBR28 MR-PET and 7T susceptibility-weighted imaging

    martes, octubre 22, 2024
    Author(s): Constantina A Treaba,Elena Herranz,Valeria T Barletta,Ambica Mehndiratta,Jacob A Sloane,Tobias Granberg,Alessandro Miscioscia,Roberto Bomprezzi,Marco L Loggia,Caterina Mainero
    Source: Multiple sclerosis (Houndmills, Basingstoke, England)
    CONCLUSION: ^(11)C-PBR28 imaging reveals more active WM lesions than 7T PRL assessment. Although PRL and PET active lesion counts are related, neurological disability is better explained by PET whole active lesion volume.

  • Development and Validation of a Clinical Score to Predict Epilepsy After Cerebral Venous Thrombosis

    lunes, octubre 21, 2024
    Author(s): Erik Lindgren,Liqi Shu,Naaem Simaan,Katarzyna Krzywicka,Maria A de Winter,Mayte Sánchez van Kammen,Jeremy Molad,Piers Klein,Hen Hallevi,Rani Barnea,Mirjam R Heldner,Sini Hiltunen,Diana Aguiar de Sousa,José M Ferro,Antonio Arauz,Jukka Putaala,Marcel Arnold,Thanh N Nguyen,Christoph Stretz,Turgut Tatlisumak,Katarina Jood,Shadi Yaghi,Ronen R Leker,Jonathan M Coutinho,DIAS research collaboration,Maryam Mansour,Patrícia Canhão,Esme Ekizoglu,Miguel Rodrigues,Elisa M Silva,Carlos Garcia-Esperon,Valentina Arnao,Shorooq Aladin,Rom Mendel,Paolo Aridon,Mine Sezgin,Andrey Alasheev,Andrey Smolkin,Daniel Guisado-Alonso,Nilufer Yesilot,Miguel A Barboza,Masoud Ghiasian,Suzanne M Silvis,Ton Fang,James E Siegler,Teddy Wu,Duncan Wilson,Syed Daniyal Asad,Sami Al Kasab,Eyad Almallouhi,Jennifer Frontera,Aaron Rothstein,Ekaterina Bakradze,Setareh Salehi Omran,Nils Henninger,Lindsey Kuohn,Adeel Zubair,Richa Sharma,Deborah Kerrigan,Yasmin Aziz,Eva Mistry,Susanna M Zuurbier
    Source: JAMA neurology
    CONCLUSIONS AND RELEVANCE: The DIAS3 score (freely available online) is a simple tool that can help predict the risk of post-CVT epilepsy in individual patients. The model can improve opportunities for personalized medicine and may aid in decision-making regarding antiseizure medication, patient counseling, and facilitation of research on epileptogenesis in CVT.

  • Endovascular therapy versus medical management in isolated posterior cerebral artery acute ischemic stroke: A multinational multicenter propensity score-weighted study

    lunes, octubre 21, 2024
    Author(s): Hamza Adel Salim,Benjamin Pulli,Vivek Yedavalli,Basel Musmar,Nimer Adeeb,Dhairya Lakhani,Muhammed Amir Essibayi,Kareem El Naamani,Nils Henninger,Sri Hari Sundararajan,Anna Luisa Kühn,Jane Khalife,Sherief Ghozy,Luca Scarcia,Inayat Grewal,Benjamin Yq Tan,Robert W Regenhardt,Jeremy J Heit,Nicole M Cancelliere,Joshua D Bernstock,Aymeric Rouchaud,Jens Fiehler,Sunil Sheth,Ajit S Puri,Christian Dyzmann,Marco Colasurdo,Xavier Barreau,Leonardo Renieri,João Pedro Filipe,Pablo Harker,Răzvan Alexandru Radu,Mohamad Abdalkader,Piers Klein,Thomas R Marotta,Julian Spears,Takahiro Ota,Ashkan Mowla,Pascal Jabbour,Arundhati Biswas,Frédéric Clarençon,James E Siegler,Thanh N Nguyen,Ricardo Varela,Amanda Baker,David Altschul,Nestor R Gonzalez,Markus A Möhlenbruch,Vincent Costalat,Benjamin Gory,Christian Paul Stracke,Mohammad Ali Aziz-Sultan,Constantin Hecker,Hamza Shaikh,Christoph J Griessenauer,David S Liebeskind,Alessandro Pedicelli,Andrea M Alexandre,Illario Tancredi,Tobias D Faizy,Erwah Kalsoum,Boris Lubicz,Aman B Patel,Vitor Mendes Pereira,Max Wintermark,Adrien Guenego,Adam A Dmytriw
    Source: European stroke journal
    CONCLUSION: EVT for iPCAo is associated with better neurological outcomes and lower mortality compared to MM, without an increased risk of hemorrhagic complications. Nevertheless, these results should be interpreted with caution due to the study's observational design. The findings are hypothesis-generating and highlight the need for future randomized controlled trials to confirm these observations and establish definitive treatment guidelines for this patient population.

  • Correction: Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Goals-of-Care and Family/Surrogate Decision-Maker Data

    martes, octubre 15, 2024
    Author(s): Matthew N Jaffa,Hannah L Kirsch,Claire J Creutzfeldt,Mary Guanci,David Y Hwang,Darlene LeTavec,Dea Mahanes,Girija Natarajan,Alexis Steinberg,Darin B Zahuranec,Susanne Muehlschlegel,Curing Coma Campaign Collaborators
    Source: Neurocritical care
    No abstract

  • Outcomes and Recurrence Rates Among Patients With Provoked and Cryptogenic Cerebral Venous Thrombosis: Analysis of the ACTION CVT

    lunes, octubre 14, 2024
    Author(s): Sami Al Kasab,Eyad Almallouhi,Liqi Shu,Kimberly P Kicielinski,Setareh Salehi Omran,David S Liebeskind,Adeel S Zubair,Maria C Vedovati,Maurizio Paciaroni,Kateryna Antonenko,Mirjam R Heldner,Adam de Havenon,Nils Henninger,Shadi Yaghi
    Source: Neurology. Clinical practice
    BACKGROUND AND OBJECTIVES: Cerebral venous thrombosis (CVT) is a rare cause of stroke. While the standard treatment is anticoagulation, the type and duration of anticoagulation depends on the underlying etiology. This study aims to identify prevalence, risk factors, and recurrent venous thromboembolism (VTE) rates among patients with idiopathic (cryptogenic) CVT and CVT provoked by transient (peripartum, hormonal treatment, infection, trauma) and persistent (cancer, thrombophilia) factors.

  • Association Between LACE+ Index Risk Category and 90-Day Mortality After Stroke

    lunes, octubre 14, 2024
    Author(s): Adalia Jun-O'Connell,Brian Silver,Eliza Grigoriciuc,Akanksha Gulati,Kimiyoshi J Kobayashi,Nils Henninger
    Source: Neurology. Clinical practice
    BACKGROUND AND OBJECTIVES: A higher LACE+ index risk category (defined as LACE+ score ≥78) typically calculated before hospital discharge has been associated with increased risk of unplanned 30-day hospital readmissions and early death after hospital discharge. However, its utility to predict poststroke mortality is unknown. Here, we examined whether the LACE+ index risk category assessed at both discharge (dLACE+) and admission (aLACE+) was associated with 90-day mortality after stroke.

  • Emerging roles of antimicrobial peptides in innate immunity, neuronal function, and neurodegeneration

    jueves, octubre 10, 2024
    Author(s): Soojin Lee,Neal Silverman,Fen-Biao Gao
    Source: Trends in neurosciences
    Antimicrobial peptides (AMPs), a collection of small proteins with important roles in classical innate immunity, have been extensively studied in multiple organisms, particularly in Drosophila melanogaster. Advances in CRISPR/Cas9 genome editing have allowed individual AMP functions to be dissected, revealing specific and selective roles in host defense. Recent findings have also revealed many unexpected contributions of endogenous AMPs to neuronal functions and neurodegenerative diseases, and...

  • Cytogenetic bands and sharp peaks of Alu underlie large-scale segmental regulation of nuclear genome architecture

    martes, octubre 08, 2024
    Author(s): Lisa L Hall,Kevin M Creamer,Meg Byron,Jeanne B Lawrence
    Source: Nucleus (Austin, Tex.)
    Cytogenetic bands reflect genomic organization in large blocks of DNA with similar properties. Because banding patterns are invariant, this organization may often be assumed unimportant for genome regulation. Results here challenge that view. Findings here suggest cytogenetic bands reflect a visible framework upon which regulated genome architecture is built. Given Alu and L1 densities differ in cytogenetic bands, we examined their distribution after X-chromosome inactivation or formation of...

  • Paramagnetic Rim Lesions are Highly Specific for Multiple Sclerosis in Real-World Data

    lunes, octubre 07, 2024
    Author(s): Christopher C Hemond,Sathish K Dundamadappa,Mugdha Deshpande,Jonggyu Baek,Robert H Brown,Carolina Ionete,Daniel S Reich
    Source: medRxiv : the preprint server for health sciences
    CONCLUSIONS: PRL convey high specificity for MS and can aid in the diagnostic evaluation. Modest sensitivity limits their use as single diagnostic indicators. Including lesions with lower confidence ("possible" PRL) rapidly erodes specificity and should be interpreted with caution given the potential harms associated with misdiagnosis.

  • Crucial role of Snf7-3 in synaptic function and cognitive behavior revealed by conventional and conditional knockout mouse models

    domingo, octubre 06, 2024
    Author(s): Hyopil Kim,Jae-Woo Jang,Su-Eon Sim,Jisu Lee,June-Hyun Jeong,Semin Park,You-Kyung Lee,Hyun-Ji Ham,Nam-Kyung Yu,Chae-Seok Lim,Fen-Biao Gao,Jin-A Lee,Bong-Kiun Kaang
    Source: Neuroscience
    Snf7-3 is a crucial component of the endosomal sorting complexes required for transport (ESCRT) pathway, playing a vital role in endolysosomal functions. To elucidate the role of Snf7-3 in vivo, we developed conventional-like and conditional Snf7-3 knockout (KO) mouse models using a "Knockout-first" strategy. Conventional-like Snf7-3 KO mice showed significantly reduced Snf7-3 mRNA expression, and older mice (25-40 weeks) exhibited impaired social recognition and increased miniature excitatory...

  • Opinion: can we bust the fear of symptomatic intracerebral hemorrhage due to tPA?

    viernes, octubre 04, 2024
    Author(s): Adalia H Jun-O'Connell
    Source: Frontiers in neurology
    No abstract

  • Curriculum Innovations: Enhancing Skills in Serious Illness Communication in Neurology Residents Using Simulation: A Pilot Study

    jueves, octubre 03, 2024
    Author(s): Marcey Osgood,Brian Silver,Jennifer Reidy,Vandana Nagpal
    Source: Neurology. Education
    BACKGROUND AND PROBLEM STATEMENT: Patients with acute ischemic stroke are faced with prognostic uncertainty, progressive decline, and early mortality. Many neurologists report a lack of education and experience in providing palliative care. We developed a simulation-based curriculum to improve residents' confidence and comfort with conducting late-stage goals of care (GOC) conversations.

  • Perineuroma Caused Isolated Footdrop

    martes, octubre 01, 2024
    Author(s): Stephen Chrzanowski,Christopher Mount,Maria Martinez-Lage,Bragi Sveinsson,Justin Brown,Reza Sadjadi
    Source: Neurology
    No abstract

  • Increasing intracellular dNTP levels improves prime editing efficiency

    miércoles, septiembre 25, 2024
    Author(s): Pengpeng Liu,Karthikeyan Ponnienselvan,Thomas Nyalile,Sarah Oikemus,Anya T Joynt,Sukanya Iyer,Karen Kelly,Dongsheng Guo,Pyae P Kyawe,Emma Vanderleeden,Sambra D Redick,Lei Huang,Zexiang Chen,Jeong Min Lee,Celia A Schiffer,David M Harlan,Jennifer P Wang,Charles P Emerson,Nathan D Lawson,Jonathan K Watts,Erik J Sontheimer,Jeremy Luban,Scot A Wolfe
    Source: Nature biotechnology
    In primary cell types, intracellular deoxynucleotide triphosphate (dNTP) levels are tightly regulated in a cell cycle-dependent manner. We report that prime editing efficiency is increased by mutations that improve the enzymatic properties of Moloney murine leukemia virus reverse transcriptase and treatments that increase intracellular dNTP levels. In combination, these modifications produce substantial increases in precise editing rates.

  • Implementation and Preliminary Evaluation of an Entrepreneurship, Biomedical Innovation, and Design Pathway in a School of Medicine Curriculum

    martes, septiembre 24, 2024
    Author(s): Nathaniel Hafer,Christian Keenan,Anindita Deb
    Source: Research square
    CONCLUSIONS: This new pathway curriculum at UMass Chan is designed to introduce students to the principles of innovation, entrepreneurship, and technology commercialization. An element of this pathway focused on basic engineering principles provided students with baseline understandings of biomedical design, human factors, and risk/hazard analysis. Despite small sample sizes, the results show improvements in student comfort with the material and knowledge. Novel curricula have the potential to...

  • Intravenous Thrombolysis in Patients With Cervical Artery Dissection: A Secondary Analysis of the STOP-CAD Study

    jueves, septiembre 19, 2024
    Author(s): Liqi Shu,Favour Akpokiere,Daniel M Mandel,Thalia S Field,Christopher R Leon Guerrero,Nils Henninger,Jayachandra Muppa,Muhammad Affan,Omair U Haq Lodhi,Mirjam R Heldner,Kateryna Antonenko,David J Seiffge,Marcel Arnold,Setareh Salehi Omran,Ross Crandall,Evan Lester,Diego López-Mena,Antonio Arauz,Ahmad Nehme,Marion Boulanger,Emmanuel Touzé,João André Sousa,João Sargento-Freitas,Vasco Barata,Paulo Castro-Chaves,Maria T Brito,Muhib Khan,Dania Mallick,Aaron Rothstein,Ossama Khazaal,Josefin E Kaufmann,Stefan T Engelter,Christopher Traenka,Diana Aguiar de Sousa,Mafalda D Soares,Sara B Rosa,Lily Zhou,Preet Gandhi,Steven Mancini,Issa Metanis,Ronen R Leker,Kelly Pan,Vishnu Dantu,Karl Baumgartner,Tina M Burton,Regina Von Rennenberg,Christian H Nolte,Richard Choi,Jason MacDonald,Reza Bavarsad Shahripour,Xiaofan Guo,Malik Ghannam,Mohammad Almajali,Edgar A Samaniego,Bastien Rioux,Faycal Zine-Eddine,Alexandre Poppe,Ana C Fonseca,Maria F Baptista,Diana Cruz,Michele Romoli,Giovanna De Marco,Marco Longoni,Zafer Keser,Kim J Griffin,Lindsey Kuohn,Jennifer A Frontera,Jordan Y Amar,James A Giles,Marialuisa Zedde,Rosario Pascarella,Ilaria Grisendi,Hipolito Nzwalo,David S Liebeskind,Amir Molaie,Annie Cavalier,Wayneho Kam,Brian Mac Grory,Sami Al Kasab,Mohammad Anadani,Kimberly P Kicielinski,Ali Eltatawy,Lina Chervak,Roberto Chulluncuy Rivas,Yasmin N Aziz,Eva A Mistry,Ekaterina Bakradze,Thanh L Tran,Marc Rodrigo-Gisbert,Manuel Requena,Faddi G Saleh Velez,Jorge Ortiz Garcia,Varsha Muddasani,Adam de Havenon,Sebastian Sanchez,Venugopalan Y Vishnu,Sridhara Yaddanapudi,Latasha Adams,Abigail Browngoehl,Tamra Ranasinghe,Randy Dunston,Zachary Lynch,Mary Penckofer,James E Siegler,Silvia Mayer,Joshua Z Willey,Adeel S Zubair,Yee Kuang Cheng,Richa Sharma,João Pedro Marto,Danna Krupka,Piers Klein,Thanh N Nguyen,Syed Daniyal Asad,Zoha Sarwat,Anvesh Balabhadra,Shivam Patel,Thais Secchi,Sheila C Martins,Gabriel P Mantovani,Young Dae Kim,Balaji Krishnaiah,Cheran Elangovan,Sivani Lingam,Abid Y Qureshi,Sebastian Fridman,Alonso Alvarado,Farid Khasiyev,Guillermo Linares,Marina Mannino,Valeria Terruso,Argyro Tountopoulou,Vasileios Tentolouris-Piperas,Manuel M Martinez-Marino,Victor Carrasco Wall,Fransisca Indraswari,Sleiman E El Jamal,Shilin Liu,Min Zhou,Muhammad M Alvi,Farman Ali,Mohammed Sarvath,Rami Z Morsi,Tareq Kass-Hout,Feina Shi,Jinhua Zhang,Dilraj Sokhi,Jamil Said,Newnex Mongare,Alexis N Simpkins,Roberto Gomez,Shayak Sen,Mohammad Ghani,Marwa Elnazeir,Runqi Wangqin,Han Xiao,Narendra S Kala,Farhan Khan,Christoph Stretz,Nahid Mohammadzadeh,Eric D Goldstein,Karen Furie,Shadi Yaghi
    Source: Neurology
    OBJECTIVES: Cervical artery dissection (CeAD) accounts for 25% of ischemic strokes in young adults. This study evaluated the benefits and harms of intravenous thrombolysis (IVT) in patients presenting with spontaneous CeAD and acute ischemic stroke symptoms.

  • Targeted proteomics of cerebrospinal fluid in treatment naïve multiple sclerosis patients identifies immune biomarkers of clinical phenotypes

    miércoles, septiembre 18, 2024
    Author(s): Alexandra Rabin,Elisa Bello,Saurabh Kumar,Dalia Abou Zeki,Khashayar Afshari,Mugdha Deshpande,Nimmy Francis,Farnaz Khalighinejad,Raffaella Umeton,Irina Radu,Fatima Qutab,Danny Kwong,Mariana Kurban,Christopher Hemond,Jillian M Richmond,Carolina Ionete
    Source: Scientific reports
    Multiple sclerosis (MS) is an inflammatory demyelinating disease with heterogeneous clinical presentations and variable long-term disability accumulation. There are currently no standard criteria to accurately predict disease outcomes. In this study we investigated the cross-sectional relationship between disease phenotype and immune-modulating cytokines and chemokines in cerebrospinal fluid (CSF). We analyzed CSF from 20 DMT-naïve MS patients using Olink Proteomics' Target 96 Inflammation panel...

  • The impact of genotype on age at loss of ambulation in individuals with Duchenne muscular dystrophy treated with corticosteroids: A single-center study of 555 patients

    miércoles, septiembre 18, 2024
    Author(s): Alexander Zygmunt,Brenda Wong,David Moon,Paul Horn,Richard Rathbun,Joshua Lambert,Jean Bange,Irina Rybalsky,Lisa Reebals,Cuixia Tian
    Source: Muscle & nerve
    INTRODUCTION/AIMS: Studies have demonstrated that certain genotypes in Duchenne muscular dystrophy (DMD) have milder or more severe phenotypes. These studies included individuals treated and not treated with corticosteroids and multiple sites with potentially varying standards of care. We aimed to assess genotype-phenotype correlations for age at loss of ambulation (LoA) in a large cohort of individuals with DMD treated with corticosteroids at one center.

  • Development and Analytical Validation of a Surface-Enhanced Raman Scattering Paper Lateral Flow Immunoassay for Detection of the Ubiquitin C-Terminal Hydrolase-L1 Traumatic Brain Injury Biomarker

    lunes, septiembre 16, 2024
    Author(s): Weirui Tan,Yingjie Hang,Anyang Wang,Jiacheng Wang,Jane G Wigginton,Susanne Muehlschlegel,Nianqiang Wu
    Source: ACS omega
    Paper lateral flow immunoassays combined with surface-enhanced Raman scattering (SERS) technology have gained increasing attention due to their high sensitivity characteristics resulting from the amplified SERS signals of the plasmon-enhanced optical probes. In contrast to conventional colorimetric lateral flow strips, SERS paper lateral flow strips (SERS-PLFSs) are currently not commercially available for widespread use. Analytical validation is the key step for commercialization. In this work,...

  • Predictive value of follow-up infarct volume on functional outcomes in middle cerebral artery M2 segment vessel occlusion stroke treated with mechanical thrombectomy

    viernes, septiembre 13, 2024
    Author(s): Vivek Yedavalli,Hamza Adel Salim,Basel Musmar,Nimer Adeeb,Kareem El Naamani,Nils Henninger,Sri Hari Sundararajan,Anna Luisa Kühn,Jane Khalife,Sherief Ghozy,Luca Scarcia,Benjamin Yq Tan,Robert W Regenhardt,Jeremy J Heit,Nicole M Cancelliere,Joshua D Bernstock,Aymeric Rouchaud,Jens Fiehler,Sunil Sheth,Ajit S Puri,Christian Dyzmann,Marco Colasurdo,Xavier Barreau,Leonardo Renieri,João Pedro Filipe,Pablo Harker,Răzvan Alexandru Radu,Mohamad Abdalkader,Piers Klein,Thomas R Marotta,Julian Spears,Takahiro Ota,Ashkan Mowla,Pascal Jabbour,Arundhati Biswas,Frédéric Clarençon,James E Siegler,Thanh N Nguyen,Ricardo Varela,Amanda Baker,Muhammed Amir Essibayi,David Altschul,Nestor R Gonzalez,Markus A Möhlenbruch,Vincent Costalat,Benjamin Gory,Christian Paul Stracke,Mohammad Ali Aziz-Sultan,Constantin Hecker,Hamza Shaikh,David S Liebeskind,Alessandro Pedicelli,Andrea M Alexandre,Illario Tancredi,Tobias D Faizy,Erwah Kalsoum,Boris Lubicz,Aman B Patel,Vitor Mendes Pereira,Adrien Guenego,Adam A Dmytriw
    Source: European stroke journal
    CONCLUSIONS: FIV within 36 h post-MT serves as a potent predictor of 90-day functional outcomes in patients with M2 segment MeVO strokes. Establishing FIV thresholds may aid in the prognostication of stroke outcomes, suggesting a role for FIV in guiding post intervention treatment decisions and informing clinical practice. Future research should focus on validating these findings across diverse patient populations and exploring the integration of FIV measurements with other clinical and imaging...

  • Mechanical Thrombectomy Versus Intravenous Thrombolysis in Distal Medium Vessel Acute Ischemic Stroke: A Multinational Multicenter Propensity Score-Matched Study

    jueves, septiembre 12, 2024
    Author(s): Hamza Adel Salim,Vivek Yedavalli,Basel Musmar,Nimer Adeeb,Muhammed Amir Essibayi,Kareem El Naamani,Nils Henninger,Sri Hari Sundararajan,Anna Luisa Kühn,Jane Khalife,Sherief Ghozy,Luca Scarcia,Benjamin Y Q Tan,Benjamin Pulli,Jeremy J Heit,Robert W Regenhardt,Nicole M Cancelliere,Joshua D Bernstock,Aymeric Rouchaud,Jens Fiehler,Sunil Sheth,Ajit S Puri,Christian Dyzmann,Marco Colasurdo,Xavier Barreau,Leonardo Renieri,João Pedro Filipe,Pablo Harker,Razvan Alexandru Radu,Thomas R Marotta,Julian Spears,Takahiro Ota,Ashkan Mowla,Pascal Jabbour,Arundhati Biswas,Frédéric Clarençon,James E Siegler,Thanh N Nguyen,Ricardo Varela,Amanda Baker,David Altschul,Nestor R Gonzalez,Markus A Möhlenbruch,Vincent Costalat,Benjamin Gory,Christian Paul Stracke,Mohammad Ali Aziz-Sultan,Constantin Hecker,Hamza Shaikh,David S Liebeskind,Alessandro Pedicelli,Andrea M Alexandre,Illario Tancredi,Tobias D Faizy,Erwah Kalsoum,Boris Lubicz,Aman B Patel,Vitor Mendes Pereira,Adrien Guenego,Adam A Dmytriw,MAD MT Investigators
    Source: Journal of stroke
    CONCLUSION: The results of this study indicate that while MT-IVT and IVT alone show similar functional and mortality outcomes in DMVO patients, MT-IVT presents a higher risk of hemorrhagic complications, thus MT-IVT may not routinely offer additional benefits over IVT alone for all DMVO stroke patients. Further prospective randomized trials are needed to identify patient subgroups most likely to benefit from MT-IVT treatment in DMVO.

  • Variability in Vowel Space in Parkinson's Disease: Associations With Cognitive and Motor Impairment

    miércoles, septiembre 11, 2024
    Author(s): Ginige S DeSilva,Prashasti Upadhyay,Michelle Manxhari,Daksha Gopal,Kara M Smith
    Source: Journal of speech, language, and hearing research : JSLHR
    CONCLUSIONS: Variability in vowel space is impacted by cognitive impairment and speech task in PwP. These findings are relevant to the further development of speech markers in PwP and other neurogenerative diseases that impact both cognitive and motor functions.

  • Identification of selective and non-selective C9ORF72 targeting in vivo active siRNAs

    jueves, septiembre 05, 2024
    Author(s): James W Gilbert,Zachary Kennedy,Bruno M D C Godinho,Ashley Summers,Alexandra Weiss,Dimas Echeverria,Brianna Bramato,Nicholas McHugh,David Cooper,Ken Yamada,Matthew Hassler,Hélène Tran,Fen Biao Gao,Robert H Brown,Anastasia Khvorova
    Source: Molecular therapy. Nucleic acids
    A hexanucleotide (G(4)C(2)) repeat expansion (HRE) within intron one of C9ORF72 is the leading genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). C9ORF72 haploinsufficiency, formation of RNA foci, and production of dipeptide repeat (DPR) proteins have been proposed as mechanisms of disease. Here, we report the first example of disease-modifying siRNAs for C9ORF72 driven ALS/FTD. Using a combination of reporter assay and primary cortical neurons derived from a...

  • Near Sequence Homology Does Not Guarantee siRNA Cross-Species Efficacy

    martes, agosto 27, 2024
    Author(s): Iris Valeria Rivera Flores,Kathryn Monopoli,Samuel Jackson,Dimas Echeverria,Daniel O'Reilly,Robert H Brown,Anastasia Khvorova
    Source: Nucleic acid therapeutics
    Small interfering RNAs (siRNAs) represent a novel class of drugs capable of potent and sustained modulation of genes across various tissues. Preclinical development of siRNAs necessitates assessing efficacy and toxicity in animal models. While identifying therapeutic leads with cross-species activity can expedite development, it may compromise efficacy and be infeasible for certain gene targets. Here, we investigate whether deriving species-active siRNAs from potent human-targeting leads-an...

  • Normative Modeling of Thalamic Nuclear Volumes and Characterization of Lateralized Volume Alterations in Alzheimer's Disease Versus Schizophrenia

    domingo, agosto 25, 2024
    Author(s): Taylor R Young,Vinod Jangir Kumar,Manojkumar Saranathan
    Source: Biological psychiatry. Cognitive neuroscience and neuroimaging
    CONCLUSIONS: In AD, thalamic nuclei are more severely and symmetrically affected, while in SCZ, the right thalamic nuclei are more affected. We highlight the right medial dorsal nucleus, which may mediate multiple symptoms of SCZ and is affected early in the disease course.