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Biochemistry and Molecular Biotechnology Department

Our mission is to illuminate the molecular mechanisms that govern basic biological processes, with an emphasis on integrative strategies to reveal fundamental mechanistic insights and develop new therapeutic paradigms empowered by a collaborative, diverse & inclusive community.

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BMB Blog Posts

Jul 31, 2024

Celebrating RNA Day with Dr. Thoru Pederson

Join us (the BMB) in celebrating RNA Day by learning more about the innovative bioengineering by the Pederson Lab.

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May 10, 2024

Dr. Brian Kelch Receives the Education Service Award, 2024

Dr. Brian Kelch received the Education Service Award in 2024! Learn more about his dedication to education in this blog post.

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Check out more of our blogs here!

Latest News

Latest BMB news as reported by the UMass Chan Communications Office

UMass Chan faculty present translational research at BRIDGE Fund Innovation Showcase

March 14, 2025
New research examines mechanisms of protein complex at basic cell biological level

January 14, 2025
PhD student among first to join UMass Chan program focused on quantitative skills

December 09, 2024
UMass Chan community invited to ponder meaning of ‘advancing together’ at art exhibit

September 25, 2024
UMass Memorial Health gift, with matching funds from UMass Foundation, to fund five new endowed chairs at UMass Chan

September 19, 2024
Convocation 2024: UMass Chan racing toward ambitious future

September 13, 2024
Morningside Graduate School of Biomedical Sciences celebrates largest class at qualifying exam ceremony

September 12, 2024
UMass Chan kicks off 2024 academic year with weeklong Convocation celebration

August 30, 2024
UMass Chan neuroscientist receives $4.1 million Transformative Research Award to study Down syndrome

July 16, 2024
UMass Chan BRIDGE Fund commits $2M in six faculty projects

July 03, 2024
Morningside Graduate School of Biomedical Sciences celebrates milestones of IMSD, PREP students

June 18, 2024
Advancing gender equity, importance of mentoring highlighted at Women’s Faculty Awards

May 24, 2024
Twenty rising faculty members graduate from Junior Faculty Development Program

May 17, 2024
Celia A. Schiffer elected to National Academy of Sciences

May 03, 2024
Mary Munson, Craig Peterson named American Association for the Advancement of Science fellows

April 18, 2024
Zhiping Weng named inaugural chair of the Department of Genomics & Computational Biology

November 03, 2023

Check out more news here!

Recent Publications

Total: 15 results

Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression

Thursday, April 17, 2025

Author(s): Amit Kumar Chakraborty,Rajnikant Dilip Raut,Kisa Iqbal,Chumki Choudhury,Thabet Alhousami,Sami Chogle,Alexa S Acosta,Lana Fagman,Kelly Deabold,Marilia Takada,Bikash Sahay,Vikas Kumar,Manish V Bais

Source: International journal of oral science
Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryoelectron tomography

Thursday, April 17, 2025

Author(s): Qiuyu J Huang,Ryan Kim,Kangkang Song,Nikolaus Grigorieff,James B Munro,Celia A Schiffer,Mohan Somasundaran

Source: Proceedings of the National Academy of Sciences of the United States of America
TMT-based Multiplexed (Chemo)proteomics on the Orbitrap Astral Mass Spectrometer

Thursday, April 10, 2025

Author(s): Yuchen He,Ka Yang,Shaoxian Li,Martin Zeller,Graeme C McAlister,Hamish I Stewart,Christian Hock,Eugen Damoc,Vlad Zabrouskov,Steven P Gygi,Joao A Paulo,Qing Yu

Source: Molecular & cellular proteomics : MCP
Molecular basis for the increased fusion activity of the Ebola virus glycoprotein epidemic variant A82V: Insights from simulations and experiments

Saturday, April 05, 2025

Author(s): Natasha D Durham,Aastha Jain,Angela Howard,Jeremy Luban,James B Munro

Source: Cell reports
Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50

Friday, April 04, 2025

Author(s): Sarah N Zvornicanin,Ala M Shaqra,Julia Flynn,Heidi Carias Martinez,Weiping Jia,Stephanie Moquin,Dustin Dovala,Daniel N Bolon,Nese Kurt Yilmaz,Celia A Schiffer

Source: mBio
Paternal Effects in Mammals: Challenges and Opportunities

Monday, March 31, 2025

Author(s): Chih-Hsiang Yang,Oliver J Rando

Source: Annual review of biochemistry
Next generation APOBEC3 inhibitors: optimally designed for potency and nuclease stability

Saturday, March 29, 2025

Author(s): Adam K Hedger,Wazo Myint,Jeong Min Lee,Diego Suchenski Loustaunau,Vanivilasini Balachandran,Ala M Shaqra,Nese Kurt Yilmaz,Jonathan K Watts,Hiroshi Matsuo,Celia A Schiffer

Source: Nucleic acids research
Animal Models of Orthopedic Implant-Associated Infections and Revisions

Monday, March 24, 2025

Author(s): Feiyang Chen,Naomi E Schiffer,Jie Song

Source: ACS biomaterials science & engineering
Genetic context of transgene insertion can influence neurodevelopment in zebrafish

Monday, March 17, 2025

Author(s): Anna J Moyer,Alexia Barcus,Mary E S Capps,Jessica A Chrabasz,Robert L Lalonde,Christian Mosimann,Summer B Thyme

Source: bioRxiv : the preprint server for biology
Citrullination of NF-κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury

Saturday, March 15, 2025

Author(s): Xin Yu,Yujing Song,Tao Dong,Wenlu Ouyang,Chao Quan,Liujiazi Shao,Leonard Barasa,Paul R Thompson,Mao Zhang,Jianjie Ma,Katsuo Kurabayashi,Yongqing Li

Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
A single cell atlas of the mouse seminal vesicle

Tuesday, March 04, 2025

Author(s): Fengyun Sun,Kathleen Desevin,Yu Fu,Shanmathi Parameswaran,Jemma Mayall,Vera Rinaldi,Nils Krietenstein,Artür Manukyan,Qiangzong Yin,Carolina Galan,Chih-Hsiang Yang,Anastasia V Shindyapina,Vadim N Glady...

Source: G3 (Bethesda, Md.)
A robust fluorogenic substrate for chikungunya virus protease (nsP2) activity

Friday, February 21, 2025

Author(s): Sparsh Makhaik,Wioletta Rut,Shruti Choudhary,Tulsi Upadhyay,Chenzhou Hao,Michael Westberg,Cedric Bobst,Euna Yoo,Jasna Fejzo,Michael Z Lin,Matthew Bogyo,Paul Thompson,Marcin Drag,Jeanne A Hardy

Source: Protein science : a publication of the Protein Society
Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila

Tuesday, February 18, 2025

Author(s): P Githure M'Angale,Adrienne Lemieux,Yumeng Liu,Shuhao Wang,Max Zinter,Gimena Alegre,Alfred Simkin,Vivian Budnik,Brian A Kelch,Travis Thomson

Source: PLoS biology
A quantitative intracellular peptide-binding assay reveals recognition determinants and context dependence of short linear motifs

Sunday, January 26, 2025

Author(s): Mythili S Subbanna,Matthew J Winters,Mihkel Örd,Norman E Davey,Peter M Pryciak

Source: The Journal of biological chemistry
Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease

Saturday, January 25, 2025

Author(s): Vincent N Azzolino,Ala M Shaqra,Akbar Ali,Nese Kurt Yilmaz,Celia A Schiffer

Source: Viruses

A full list of department publications can be found here.

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January 2023

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Jake Landeck (Kelch Lab)
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Adam Hedger (Watts/Schiffer Lab)
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Sarah Zvornicanin (Schiffer Lab)
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Monserrat Olea-Flores (Imbalzano Lab)
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